ChloroquineV1, Main, Exploration, bibRecord, 003635

Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin

Identifieur interne : 003635 ( Main/Exploration ); précédent : 003634; suivant : 003636

Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin

Auteurs : Timothy G. Geary [États-Unis] ; Edward J. Delaney [États-Unis] ; Irving M. Klotz [États-Unis] ; James B. Jensen [États-Unis]

Source :

Molecular & Biochemical Parasitology [ 0166-6851 ] ; 1983.

RBID : ISTEX:743D7016D02186C01D04B17661B6B226E1627357

English descriptors

Teeft :
- Acetaminophen, Acetylsalicylic acid, Antimalarial, Antimalarial activity, Antimalarial effects, Aspirin, Cathepsin, Chloroquine, Continuous exposure, Covalent, Covalent modification, Dbnf, Derivative, Dibromoaspirin, Diester, Diesters, Erythrocyte, Erythrocyte membrane, Erythrocytes pretreated, Falciparum, Final parasitemia, Fumarate, Hemoglobin, Human serum, Ibuprofen, Indomethacin, Initial exposure, Klotz, Malaria, Malaria parasites, Modification, Other experiments, Parasite, Parasite development, Parasite protease, Parasite proteases, Parasite survival, Parasitemia, Parasitol, Phenylbutazone, Plasmodium, Plasmodium falciparum, Plasmodiumfalciparum, Pretreated, Pretreated erythrocytes, Protease, Ring stage, Ring stage parasites, Rpmi, Schizonts, Succinate, Trophozoite.

Abstract

Abstract: Antimalarial effects might be expected from compounds that modify hemoglobin. Dibromoaspirin and bis(dibromosalicyl) diesters decrease gelation of hemoglobin by specific covalent modification (acetylation and crosslinking) of this protein but do not interfere with oxygen transport. These compounds were toxic to malaria parasites when continuously present in culture, as were drugs with similar pharmacological effects such as indomethacin, ibuprofen, and phenylbutazone. Aspirin and acetaminophen were much less effective. When erythrocytes were pretreated with these compounds prior to parasite exposure, only dibromoaspirin and dibromosalicyl diesters prevented parasite development. The modified hemoglobin was highly resistant to digestion by cathepsin D and parasite proteases, suggesting that covalent modifications of hemoglobin that do not disrupt normal hemoglobin function have antimalarial effects.

Url:

https://api.istex.fr/ark:/67375/6H6-DDTSTLQ8-W/fulltext.pdf

DOI: 10.1016/0166-6851(83)90057-9

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000F81
to stream Istex, to step Curation: 000F81
to stream Istex, to step Checkpoint: 002395
to stream Main, to step Merge: 003712
to stream Main, to step Curation: 003635

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin</title>
<author><name sortKey="Geary, Timothy G" sort="Geary, Timothy G" uniqKey="Geary T" first="Timothy G." last="Geary">Timothy G. Geary</name>
</author>
<author><name sortKey="Delaney, Edward J" sort="Delaney, Edward J" uniqKey="Delaney E" first="Edward J." last="Delaney">Edward J. Delaney</name>
</author>
<author><name sortKey="Klotz, Irving M" sort="Klotz, Irving M" uniqKey="Klotz I" first="Irving M." last="Klotz">Irving M. Klotz</name>
</author>
<author><name sortKey="Jensen, James B" sort="Jensen, James B" uniqKey="Jensen J" first="James B." last="Jensen">James B. Jensen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:743D7016D02186C01D04B17661B6B226E1627357</idno>
<date when="1983" year="1983">1983</date>
<idno type="doi">10.1016/0166-6851(83)90057-9</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-DDTSTLQ8-W/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000F81</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F81</idno>
<idno type="wicri:Area/Istex/Curation">000F81</idno>
<idno type="wicri:Area/Istex/Checkpoint">002395</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002395</idno>
<idno type="wicri:doubleKey">0166-6851:1983:Geary T:inhibition:of:the</idno>
<idno type="wicri:Area/Main/Merge">003712</idno>
<idno type="wicri:Area/Main/Curation">003635</idno>
<idno type="wicri:Area/Main/Exploration">003635</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin</title>
<author><name sortKey="Geary, Timothy G" sort="Geary, Timothy G" uniqKey="Geary T" first="Timothy G." last="Geary">Timothy G. Geary</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Public Health, Michigan State University, East Lansing, MI 48824-1101</wicri:regionArea>
<placeName><region type="state">Michigan</region>
<settlement type="city">East Lansing</settlement>
</placeName>
<orgName type="university">Université d'État du Michigan</orgName>
</affiliation>
</author>
<author><name sortKey="Delaney, Edward J" sort="Delaney, Edward J" uniqKey="Delaney E" first="Edward J." last="Delaney">Edward J. Delaney</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry, Northwestern University, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klotz, Irving M" sort="Klotz, Irving M" uniqKey="Klotz I" first="Irving M." last="Klotz">Irving M. Klotz</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry, Northwestern University, Evanston, IL 60201</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jensen, James B" sort="Jensen, James B" uniqKey="Jensen J" first="James B." last="Jensen">James B. Jensen</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Public Health, Michigan State University, East Lansing, MI 48824-1101</wicri:regionArea>
<placeName><region type="state">Michigan</region>
<settlement type="city">East Lansing</settlement>
</placeName>
<orgName type="university">Université d'État du Michigan</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Molecular & Biochemical Parasitology</title>
<title level="j" type="abbrev">MOLBIO</title>
<idno type="ISSN">0166-6851</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1983">1983</date>
<biblScope unit="volume">9</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="59">59</biblScope>
<biblScope unit="page" to="72">72</biblScope>
</imprint>
<idno type="ISSN">0166-6851</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0166-6851</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetaminophen</term>
<term>Acetylsalicylic acid</term>
<term>Antimalarial</term>
<term>Antimalarial activity</term>
<term>Antimalarial effects</term>
<term>Aspirin</term>
<term>Cathepsin</term>
<term>Chloroquine</term>
<term>Continuous exposure</term>
<term>Covalent</term>
<term>Covalent modification</term>
<term>Dbnf</term>
<term>Derivative</term>
<term>Dibromoaspirin</term>
<term>Diester</term>
<term>Diesters</term>
<term>Erythrocyte</term>
<term>Erythrocyte membrane</term>
<term>Erythrocytes pretreated</term>
<term>Falciparum</term>
<term>Final parasitemia</term>
<term>Fumarate</term>
<term>Hemoglobin</term>
<term>Human serum</term>
<term>Ibuprofen</term>
<term>Indomethacin</term>
<term>Initial exposure</term>
<term>Klotz</term>
<term>Malaria</term>
<term>Malaria parasites</term>
<term>Modification</term>
<term>Other experiments</term>
<term>Parasite</term>
<term>Parasite development</term>
<term>Parasite protease</term>
<term>Parasite proteases</term>
<term>Parasite survival</term>
<term>Parasitemia</term>
<term>Parasitol</term>
<term>Phenylbutazone</term>
<term>Plasmodium</term>
<term>Plasmodium falciparum</term>
<term>Plasmodiumfalciparum</term>
<term>Pretreated</term>
<term>Pretreated erythrocytes</term>
<term>Protease</term>
<term>Ring stage</term>
<term>Ring stage parasites</term>
<term>Rpmi</term>
<term>Schizonts</term>
<term>Succinate</term>
<term>Trophozoite</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Antimalarial effects might be expected from compounds that modify hemoglobin. Dibromoaspirin and bis(dibromosalicyl) diesters decrease gelation of hemoglobin by specific covalent modification (acetylation and crosslinking) of this protein but do not interfere with oxygen transport. These compounds were toxic to malaria parasites when continuously present in culture, as were drugs with similar pharmacological effects such as indomethacin, ibuprofen, and phenylbutazone. Aspirin and acetaminophen were much less effective. When erythrocytes were pretreated with these compounds prior to parasite exposure, only dibromoaspirin and dibromosalicyl diesters prevented parasite development. The modified hemoglobin was highly resistant to digestion by cathepsin D and parasite proteases, suggesting that covalent modifications of hemoglobin that do not disrupt normal hemoglobin function have antimalarial effects.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Michigan</li>
</region>
<settlement><li>East Lansing</li>
</settlement>
<orgName><li>Université d'État du Michigan</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Michigan"><name sortKey="Geary, Timothy G" sort="Geary, Timothy G" uniqKey="Geary T" first="Timothy G." last="Geary">Timothy G. Geary</name>
</region>
<name sortKey="Delaney, Edward J" sort="Delaney, Edward J" uniqKey="Delaney E" first="Edward J." last="Delaney">Edward J. Delaney</name>
<name sortKey="Jensen, James B" sort="Jensen, James B" uniqKey="Jensen J" first="James B." last="Jensen">James B. Jensen</name>
<name sortKey="Klotz, Irving M" sort="Klotz, Irving M" uniqKey="Klotz I" first="Irving M." last="Klotz">Irving M. Klotz</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003635 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003635 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:743D7016D02186C01D04B17661B6B226E1627357
   |texte=   Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin

Inhibition of the growth of Plasmodium falciparum in vitro by covalent modification of hemoglobin

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri